In vitro cytotoxic activity of bark extracts from Pinus durangensis Martinez and Quercus sideroxyla Bonpl.

Autores/as

  • Marcela Soto-García
  • Martha Rosales-Castro
  • José Rubén García-Sánchez
  • María José Rivas Arreola Ibero Puebla

DOI:

https://doi.org/10.18633/biotecnia.v24i1.1520

Palabras clave:

extractos de corteza, citotoxicidad, perfil fenólico

Resumen

En la actualidad, los compuestos bioactivos de las plantas representan un gran potencial para descubrir un fármaco novedoso que pueda actuar en el tratamiento del cáncer. Se ha informado que diferentes especies de pino y roble poseen actividades citotóxicas contra varias líneas celulares cancerosas. En el presente estudio, se evaluo el perfil fenólico y las actividades citotóxicas de extractos crudos y orgánicos de la corteza de P. durangensis y Q. sideroxyla. Algunos compuestos, como los dímeros de taxifolina y procianidina, fueron identificados en extractos de ambas especies mediante ESI-MS. La actividad citotóxica se realizó en MDA-MB-231 (cáncer de mama), HeLa (cáncer de cuello uterino), MCF-10A (células no tumorales de mama) y HSF-1184 (células de fibroblastos de piel humana) mediante ensayo MTT. Todos los extractos mostraron un efecto citotóxico dependiente de la dosis contra las líneas celulares cancerosas y poca o ninguna actividad contra las no tumorales. Los resultados proporcionan información importante sobre la actividad citotóxica de extractos de corteza de P. durangensis y Q. sideroxyla.

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Publicado

2022-02-23

Cómo citar

Soto-García, M. ., Rosales-Castro, M. ., García-Sánchez, J. R. ., & Rivas Arreola, M. J. (2022). In vitro cytotoxic activity of bark extracts from Pinus durangensis Martinez and Quercus sideroxyla Bonpl. Biotecnia, 24(1), 55–61. https://doi.org/10.18633/biotecnia.v24i1.1520

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