Actividad antifúngica de extractos metanólicos y alcaloides de Jatropha platyphylla contra Aspergillus parasiticus

Autores/as

DOI:

https://doi.org/10.18633/biotecnia.v22i3.1216

Palabras clave:

antifúngico, extracto, alcaloide, identificación, Jatropha platyphylla.

Resumen

Los metabolitos secundarios presentes en plantas han demostrado ejercer diversas propiedades biológicas, principalmente el grupo de alcaloides, los cuales han sido investigados por su actividad fungicida, capaz de reemplazar a los productos sintéticos. Las especies del género Jatropha han sido estudiadas por su amplia variedad de metabolitos secundarios con potencial antimicrobiano, logrando ser relevantes en la búsqueda de nuevas alternativas al control de hongos de importancia clínica y alimentaria como Aspergillus parasiticus, considerado como una de las principales especies de hongos productores de aflatoxinas.

En el presente trabajo se identificó por primera vez por cromatografía en capa fina de alta resolución (HPTLC) la presencia de alcaloides en Jatropha platyphylla y se evaluó la actividad inhibitoria de los extractos metanólicos y fracción enriquecida de alcaloides, a concentraciones de 0.01, 0.1, 0.5, 1 y 2 mg/mL, sobre el crecimiento radial de A. parasiticus. Además se determinó su germinación a partir de la CI50 de los tratamientos. Se observó una mayor actividad de los alcaloides a 2 mg/mL, con el 80 % de inhibición a las 48 h  (P< 0,05), con una CI50 de 2.7 mg/mL. Estos resultados evidencian a los alcaloides de J. platyphylla como posibles tratamientos alternativos al control de A. parasiticus.

Biografía del autor/a

Mario Alejandro Leyva AcuÑa, Centro de Investigación en Alimentación y Desarrollo

Maestro en Ciencias

Eber Addí Quintana Obregón, Centro de Investigación en Alimentación y Desarrollo

Catedra de CONACYT

Federico Soto Landeros, Centro de Investigación en Alimentación y Desarrollo

Laboratorio de biorecursos, Postdoctorado

Karla Marina Baez Parra, Universidad Autónoma de Sinaloa

Doctora en ciencias

Julio Montes Avila, Universidad Autónoma de Sinaloa

Laboratorio de Química de Productos Naturales

Miguel Angel Angulo Escalante, Centro de Investigación en Alimentación y Desarrollo

Laboratorio de biorecursos, encargado del laboratorio

Citas

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2020-09-21

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