Cambios fisiopatológicos renales en hamster sirio-dorado (Mesocricetus auratus) diabéticos alimentados con dieta hipercalórica
DOI:
https://doi.org/10.18633/biotecnia.v26.2420Palabras clave:
fibrosis, nefropatía, dieta hipercalórica, diabético, histopatológicoResumen
La nefropatía diabética es la principal causa de insuficiencia renal terminal. El aumento del tejido adiposo visceral puede provocar hipertrofia glomerular y enfermedad renal crónica. El objetivo es determinar los cambios renales en hámster sirio dorado (Mesocricetus auratus) diabéticos suplementados con una dieta hipercalórica. Métodos: Un grupo de animales (n=10) alimentado con dieta estándar (SD) y otro (n=10) con dieta hipercalórica (HCD) durante 1 mes. Posteriormente, ambos grupos fueron tratados con tres dosis de Estreptozotocina. La hiperglucemia se determinó durante 73 días. Se obtuvo el peso de los animales, sangre y tejido renal. Resultados: Los animales diabéticos alimentados con HCD manifestaron hiperglucemia (250-350 mg/dL) con pérdida de peso significativa (40g), disminución del filtrado glomerular (0,491mL/min) y aumento de la matriz extracelular glomerular, intersticial y cortical (36,3, 75,2 y 70,7%, respectivamente). Los animales diabéticos que fueron alimentados con SD mostraron sólo una hiperglucemia leve y un ligero aumento de la matriz extracelular glomerular, intersticial y cortical. Un grupo de animales (n=5) alimentados exclusivamente con HCD fue incluido en el estudio. Conclusiones: Nuestro hallazgo sugiere que la alimentación con HCD puede acelerar la progresión de la enfermedad renal crónica en una condición diabética.
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