Extractos polifenólicos de las hojas de Ilex paraguariensis y Larrea divaricata y su potencial antioxidante y antiCOVID-19


  • Juan C. Contreras-Esquivel Universidad Autónoma de Coahuila
  • Carlos N. Cano-González Universidad Autónoma de Coahuila
  • Juan Ascacio-Valdes Universidad Autónoma de Coahuila
  • Jorge A. Aguirre-Joya Universidad Autónoma de Coahuila
  • David Aguillón-Gutierrez Universidad Autónoma de Coahuila
  • Javier Breccia National University of la Pampa
  • Judith D. Espinoza-Perez Coyotefoods
  • Cristóbal N. Aguilar Universidad Autónoma de Coahuila
  • Cristian Torres León Universidad Autónoma de Coahuila https://orcid.org/0000-0002-1614-5701



Palabras clave:

COVID-19, phenolic compounds, Ilex paraguariensis


Las hojas de yerba mate (Ilex paraguariensis A.St. Hil) y jarilla (Larrea divaricata Cav.) se usan comúnmente como infusión de té en algunos países de América Latina. Este estudio se realizó para evaluar la actividad antioxidante (FRAP, ABTS y DPPH) y el potencial inhibitorio de los extractos de yerba mate y jarilla sobre la proteasa 3CL (Mpro) de coronavirus SARS-COV-2 por enfoque de acoplamiento molecular. Los principales compuestos bioactivos presentes en los extractos de plantas fueron identificados por HPLC-MS. De acuerdo con los resultados, los extractos polifenólicos de yerba mate y jarilla presentaron alta actividad antioxidante en los ensayos DPPH (> 91 %), ABTS (> 90 %) y FRAP (> 47 mg TE/g). Además, los compuestos fenólicos presentes en la yerba mate, quercetina-3-O-rutinósido (rutina) (-9,60 kcal/mol) y ácido 3,4-dicafeoilquínico (-8,20 kcal/mol) han demostrado ser más efectivos (en Mpro) que los medicamentos antivirales remdesivir y ribavirin. Los compuestos rutina y ácido 3,4-dicafeoilquínico tienen alta afinidad e interacción con uno de los residuos catalíticos Cys145 de Mpro. Estos resultados sugieren que las hojas de yerba mate y jarilla podrían potenciar las defensas antioxidantes del organismo y podrían beneficiar la salud.


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Cómo citar

Contreras-Esquivel, J. C., Cano-González, C. N. ., Ascacio-Valdes, J. ., Aguirre-Joya, J. A. ., Aguillón-Gutierrez, D., Breccia, J. ., Espinoza-Perez, J. D. ., Aguilar, C. N. ., & Torres León, C. (2022). Extractos polifenólicos de las hojas de Ilex paraguariensis y Larrea divaricata y su potencial antioxidante y antiCOVID-19. Biotecnia, 25(1), 61–66. https://doi.org/10.18633/biotecnia.v25i1.1762



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