Potencial anti-estrés nitrosativo y oxidativo, y anti-inflamatorio de una fracción citoprotectora aisla-da de Litopenaeus stylirostris
Potencial anti-estrés nitrosativo y oxidativo, y anti-inflamatorio de una fracción citoprotectora aisla-da de Litopenaeus stylirostris
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https://doi.org/10.18633/biotecnia.v27.2425Palabras clave:
citocinas, especies reactivasResumen
Se realizaron actividades biológicas de una fracción aislada del músculo de Litopenaeus stylirostris, la cual contiene un nuevo compuesto bioactivo derivado del alcaloide indolocarbazol, el ácido eicosapentaenoico y el dioctil ftalato. Se estudió la actividad eliminadora de especies reactivas de nitrógeno (ERN), la inhibición de la producción de óxido nítrico (ON), la reducción de especies reactivas de oxígeno (ERO) y la producción de citocinas reguladoras. Los resultados mostraron que la fracción disminuye los niveles de ERN, ON y ERO intracelulares; además, se encontró que es capaz de regular positivo y negativamente las citoquinas antiinflamatorias y proinflamatorias, respectivamente; lo que sugiere la presencia de compuestos que podrían estar asociados con disminuciones del estrés nitrosativo y oxidativo, así como con procesos de inflamación.
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