Polimorphism in the PAPPA2 gene associated with postpartum fertility in Holstein milking cows managed under warm conditions in southern Sonora Mexico
DOI:
https://doi.org/10.18633/biotecnia.v26.2261Keywords:
dairy cattle, DNA, hot climate, reproduction, SNPAbstract
Reproductive management in dairy cows in southern Sonora is a challenge due to the characteristic hot climate, then genetic selection for fertility is desirable. The objective was to study the association between single nucleotide polymorphisms (SNPs) from the PAPPA2 gene and postpartum fertility traits in lactating Holstein cows. A total of 362 cows were included in this study. Individual blood samples were collected on FTA cards, which were used for DNA extraction and genotyping of two PAPPA2 gene SNPs. An associative study was then performed between the genotypes of the SNPs and postpartum reproductive traits using a statistical mixed-effects model. Only the SNP rs109952914 was associated with all fertility traits and retained for allele substitution analysis. The favorable allele of the SNP rs109952914 was the T allele (P < 0.05), as it increased the percentage of pregnancy at first service (+ 12.60), and reduced services per conception (- 0.16) and days open (- 19.52). In conclusion, a SNP within the PAPPA2 gene was a predictor of postpartum fertility in Holstein dairy cows; then, it was recommended to be used as genetic marker in animal breeding programs to increase reproductive efficiency in Holstein dairy cattle managed under warm environmental conditions.
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