Composición química, actividad antioxidante y citotoxicidad de extractos de flores de Magnolia grandiflora L. encontradas en el sureste de México


  • Tomás Rivas-García CONACYT-Universidad Autonoma Chapingo
  • Jorge Alberto Alejandre-Rosas Facultad de Ciencias Químicas, Universidad Veracruzana, Oriente 6 1009, Col. Rafael Alvarado, Orizaba 94340, Veracruz, México.
  • Ángel Ramos-Ligonio Facultad de Ciencias Químicas, Universidad Veracruzana, Oriente 6 1009, Col. Rafael Alvarado, Orizaba 94340, Veracruz, México.
  • Marisol Castillo-Morales Facultad de Ciencias Químicas, Universidad Veracruzana, Oriente 6 1009, Col. Rafael Alvarado, Orizaba 94340, Veracruz, México.
  • Juan José Reyes-Pérez Universidad Técnica Estatal de Quevedo, Av. Quito Km 1.5 Vía a Santo Domingo, Quevedo, Los Ríos, Ecuador
  • Berenice Esquivel-Valenzuela Universidad Autónoma Chapingo, Unidad Regional Universitaria de Zonas Áridas, Carretera Gómez Palacio-Ciudad Juárez, domicilio conocido, Bermejilo 35230, Durango, México.


Palabras clave:

Actividad biológica, Compuestos bioactivos, Plantas medicinales


Muchos estudios afirman que diferentes estructuras de M. grandiflora contienen componentes bioactivos. No obstante, los estudios fitoquímicos indican que los aceites esenciales extraídos son químicamente diferentes y notablemente variables en sus composiciones cualitativas y cuantitativas. Es necesario realizar más estudios sobre M. grandiflora cultivada en México. Por ello, el objetivo de esta investigación fue caracterizar a) la composición química, b) la actividad antioxidante y c) el efecto citotóxico de dos extractos de flores de M. grandiflora. La composición química se evaluó mediante una prueba fitoquímica preliminar seguida de cromatografía en capa fina y análisis espectrofotómetro mediante UV-Vis y FTIR. La actividad antioxidante de los extractos de flores se midió por el método de la actividad reductora de radicales libres (ABTS) y el método de radicales estables de 2,2-difenil-1-picril-hidrazilo (DPPH) y la citotoxicidad por un bioensayo de Artemia salina. Los extractos acuoso y etílico de flores mostraron la presencia de cromóforos orgánicos como los flavonoides. Ambos extractos (etilo y agua) demostraron actividad antioxidante tanto por ABTS (459,6 ± 8,5 µmol TE g-1 y 274,2 ± 5,7 µmol TE g-1 respectivamente) como por DPPH (3210,4 ± 2,5 µmol TE g-1 y 219,7 ± 0,9 µmol TE g-1 respectivamente) metodologías; y actividad no citotóxica (CL50, µg mL-1) (1,285±14 y 1,116±15 respectivamente). Los extractos acuosos y etílicos de las flores de M. grandiflora encontradas en el sureste de México son una fuente promisoria de compuestos químicos con actividad biológica atribuida por los resultados presentados.


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Cómo citar

Rivas-García, T., Alejandre-Rosas, J. A. ., Ramos-Ligonio, Ángel, Castillo-Morales, M. ., Reyes-Pérez, J. J. ., & Esquivel-Valenzuela, B. . (2022). Composición química, actividad antioxidante y citotoxicidad de extractos de flores de Magnolia grandiflora L. encontradas en el sureste de México . Biotecnia, 25(1), 5–13.



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