FOOD MATRICES FOR THE DELIVERY OF ANTIHYPERTENSIVE PEPTIDES IN FUNCTIONAL FOODS

Authors

  • GI Ramírez-Torres Departamento de Ciencias Químico Biológicas, Universidad de Sonora. Hermosillo, Sonora, 83000, México. Escuela Superior de Educación Física, Universidad Autónoma de Sinaloa. Culiacán, Sinaloa 80019, México.
  • N Ontiveros Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora. Navojoa, Sonora 85880, México
  • V López-Teros Departamento de Ciencias Químico Biológicas, Universidad de Sonora. Hermosillo, Sonora, 83000, México
  • GM Suarez-Jiménez Departamento de Investigación y Posgrado en Alimentos. Universidad de Sonora. Hermosillo, Sonora, 83000, México
  • F Cabrera-Chávez Unidad Académica de Ciencias de la nutrición y Gastronomía. Universidad Autónoma de Sinaloa. Culiacán, Sinaloa 80019, México

DOI:

https://doi.org/10.18633/biotecnia.v20i3.723

Keywords:

Bioactive compounds, Food matrix, Bioavailability

Abstract

Many food-derived peptides with antihypertensive activity have been reported. However, a reduced number of studies have been conducted to prove in vivo the efficacy of most of the currently reported antihypertensive peptides. Thus, just a few of these bioactive peptides are utilized as supplements or ingredients for functional foods production. In addition to in vivo evaluations, another challenging task is the delivery of bioactive peptides in physiological conditions, but studies about this topic are scarce. Notably, some proteins are able to form gels that have different characteristics related to the pH of the environment. Bioactive peptides can be entrapped into such gels structure and be released in different physiological environments (e. g. low pH in the stomach and neutral in the intestine). Thus, the selection of macronutrients could play a critical role in the design of food matrices intended to be used as containers and releasers of antihypertensive peptides.

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References

Aggett, P.J. 2010. Population reference intakes and micronutrient bioavailability: a European perspective. The American journal of clinical nutrition. 91: 1433S-1337S.

Aluko, R. E. 2015. Antihypertensive peptides from food proteins. Annual review of food science and technology. 6: 235-262.

Balasundram, N., Sundram, K. and Samman, S. 2006. Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food chemistry. 99: 191-203.

Beltrán-Barrientos, L., Hernández-Mendoza, A., Torres-Llanez, M., González-Córdova, A. and Vallejo-Córdoba, B. 2016. Invited review: Fermented milk as antihypertensive functional food. Journal of dairy science.

Camenisch, G., Alsenz, J., van de Waterbeemd, H. and Folkers, G.1998 Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs’ lipophilicity and molecular weight. European journal of pharmaceutical sciences. 6: 313-319.

Cian, R. E., Garzón, A. G., Ancona, D. B., Guerrero, L. C., and Drago, S. R. 2015. Hydrolyzates from Pyropia columbina seaweed have antiplatelet aggregation, antioxidant and ACE I inhibitory peptides which maintain bioactivity after simulated gastrointestinal digestion. LWT-Food Science and Technology. 64: 881-888.

Cicero, A., Rosticci, M., Ferroni, A., Bacchelli, S., Veronesi, M., Strocchi, E., and Borghi, C. 2012. Predictors of the Short-Term Effect of Isoleucine–Proline–Proline/Valine–Proline–Proline Lactotripeptides from Casein on Office and Ambulatory Blood Pressure in Subjects with Pharmacologically Untreated High-Normal Blood Pressure or First-Degree Hypertension.

Clinical and Experimental Hypertension. 34: 601-605.

Ding, L., Wang, L., Zhang, Y. and Liu, J. 2015. Transport of Antihypertensive Peptide RVPSL, Ovotransferrin 328–332, in Human Intestinal Caco-2 Cell Monolayers. Journal of agricultural and food chemistry. 63: 8143-8150.

Dziuba, B. and Dziuba, M. 2014. Milk proteins-derived bioactive peptides in dairy products: molecular, biological and methodological aspects. Acta Scientiarum Polonorum Technologia Alimentaria. 13, 5-26.

Flores, F. P., and Kong, F. 2017. In Vitro Release Kinetics of Microencapsulated Materials and the Effect of the Food Matrix. Annual Review of Food Science and Technology, 8: 237-259.

Freeman, H.J. 2015. Clinical relevance of intestinal peptide uptake. World journal of gastrointestinal pharmacology and therapeutics. 6: 22.

Foegeding, E.A. 2006. Food biophysics of protein gels: A challenge of nano and macroscopic proportions. Food Biophysics. 1: 41-50.

Foegeding, E. A., Plundrich, N., Schneider, M., Campbell, C., and Lila, M. A. 2017. Protein-polyphenol particles for delivering structural and health functionality. Food Hydrocolloids.

García, M., Puchalska, P., Esteve, C., and Marina, M. 2013. Vegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities. Talanta. 106: 328-349.

Gleeson, J. P., Brayden, D. J. and Ryan, S. M. 2017. Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models. European Journal of Pharmaceutics and Biopharmaceutics. 115: 276-284.

Hernández-Ledesma, B., del Mar Contreras, M., and Recio, I. 2011. Antihypertensive peptides: production, bioavailability and incorporation into foods. Advances in colloid and interface science. 165: 23-35.

Ishida, Y., Shibata, Y., Fukuhara, I., Yano, Y., Takehara, I., and Kaneko, K. 2011. Effect of an excess intake of casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro in subjects with normal blood pressure, high-normal blood pressure, or mild hypertension. Bioscience, biotechnology, and biochemistry., 75: 427-433.

Kohlmeier, M. 2015. Absortion, transport and retention. En: Nutrient Metabolism: Structures, Functions, and Genes. Kohlmeier, M (2ed.), pp 37-87. Elsevier Ltd., New York.

Li-Chan, E.C. 2015. Bioactive peptides and protein hydrolysates: research trends and challenges for application as nutraceuticals and functional food ingredients. Current Opinion in Food Science 1: 28-37.

Maeno, M., Yamamoto, N. and Takano, T. 1996. Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. Journal of Dairy Science. 79: 1316-1321.

Mandalari, G., Rigby, N.M., Bisignano, C., Curto, R.B.L., Mulholland, F., Su. M., Venkatachalam, M., Robotham, J.M., Willison, L.N., Lapsley, K., Roux, K.H. and Sathe, S.K. 2014. Effect of food matrix and processing on release of almond protein during simulated digestion. LWT-Food Science and Technology. 59: 439-447.

Martínez-Maqueda, D., Miralles, B., Recio, I. and Hernández- Ledesma, B. 2012 Antihypertensive peptides from food proteins: a review. Food & Function. 3: 350-361.

Moretti, D., Zimmermann, M.B.,Wegm¨uller, R.,Walczyk, T., Zeder, C. and Hurrell, R.F. 2006. Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans. The American journal of clinical nutrition, 83: 632-638.

Norris, R. and FitzGerald, R.J. 2013. Antihypertensive peptides from food proteins, in Bioactive Food Peptides in Health and Disease. InTech. 45-61.

Parada, J. and Aguilera, J. 2007. Food microstructure affects the bioavailability of several nutrients. Journal of food science. 72: R21-R32.

Pauletti, G.M., Okumu, F.W. and Borchardt, R.T. 1997. Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway. Pharmaceutical research 14: 164-168.

Peppas, N.A. and Kavimandan, N.J. 2006. Nanoscale analysis of protein and peptide absorption: insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles. European Journal of Pharmaceutical Sciences 29: 183-197.

Qureshi, M., Karthikeyan, S., Karthikeyan, P., Khan, P., Uprit, S. and Mishra, U. 2012. Application of nanotechnology in food and dairy processing: an overview. Pak J Food Sci. 22: 23-31.

Rutella, G. S., Solieri, L., Martini, S. and Tagliazucchi, D. 2016. Release of the Antihypertensive Tripeptides Valine-Proline- Proline and Isoleucine-Proline-Proline from Bovine Milk Caseins during in Vitro Gastrointestinal Digestion. Journal of agricultural and food chemistry. 64: 8509-8515.

Schobert, B. and Tschesche, H. 1978. Unusual solution properties of proline and its interaction with proteins. Biochimica et Biophysica Acta (BBA)-General Subjects. 541: 270-277.

Ten Have, G.A., van der Pijl, P.C., Kies, A.K. and Deutz, N.E. 2015. Enhanced Lacto-Tri-Peptide Bio-Availability by Co-Ingestion of Macronutrients. PloS one. 10:.

US National Institutes of Health. [consultado 17 Agosto 2017]. Disponble en https://clinicaltrials.gov.

Wada, Y., and Lönnerdal, B. 2014. Bioactive peptides derived from human milk proteins—mechanisms of action. The Journal of nutritional biochemistry. 25: 503-514.

Zúñiga, R.N. and Troncoso, E. 2012. Improving nutrition through the design of food matrices, in Scientific Health and Social Aspects of the Food Industry, ed by Valdez B. Rijeka. 295-320.

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Published

2018-09-07

How to Cite

Ramírez-Torres, G., Ontiveros, N., López-Teros, V., Suarez-Jiménez, G., & Cabrera-Chávez, F. (2018). FOOD MATRICES FOR THE DELIVERY OF ANTIHYPERTENSIVE PEPTIDES IN FUNCTIONAL FOODS. Biotecnia, 20(3), 165–169. https://doi.org/10.18633/biotecnia.v20i3.723

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