Actividad Antioxidante, Antiproliferativa y Antibacteriana de Extractos de Phoradendron californicum; una Planta Parásita del Noroeste de México
DOI:
https://doi.org/10.18633/biotecnia.v26.2286Palabras clave:
Phoradendron californicum, Antriproliferative activity, Antibacterial activity, Antioxidant activity, Natural extracts, Mexican plantsResumen
Phoradendron californicum es una planta presente en el noroeste de México que se ha empleado como alternativa terapéutica. En el presente estudio se realizaron extractos metanólicos y clorofórmicos de P. californicum y se evaluaron sus actividades antioxidantes, contenido de fenoles y flavonoides, así como su actividad antiproliferativa en células de cáncer. El extracto metanólico presentó mayor actividad antioxidante (IC50: 47.62 ± 2.90 μg/mL) y un mayor contenido de fenoles totales (186.45 ± 4.58 μg/mL) en comparación con el extracto clorofórmico (IC50: ˃400 μg/mL y 13.54 ± 1.57 μg/mL, respectivamente), ambos extractos presentaron contenido similar de flavonoides totales (19.92 ± 1.84 y 25.55 ± 0.73 μg/mL, respectivamente). Por otra parte, el extracto clorofórmico presentó mayor actividad antiproliferativa en las líneas celulares evaluadas (HeLa, PC3 y L929) en comparación con el extracto metanólico. Mientras tanto el extracto clorofórmico presentó mayor actividad contra Escherichia coli y Listeria monocytogenes, mientras que el extracto metanólico presentó mayor actividad contra Salmonella entérica. La clara diferencia en las actividades biológicas de ambos extractos puede deberse a las diferencias en la composición química de cada uno debido al método de extracción utilizado. P. californicum tiene potencial para la búsqueda de nuevos compuestos con actividad biológica.
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